In the years I've been doing this I don't believe I've ever guessed both Sound categories correctly (though I've come awfully close). This year has me similarly unsure of myself, as both categories could come down to either of two movies.

The obvious choice in this category,
Inception, may actually be less safe than assumed. There's no denying the sophistication of the mix, and the sheer volume of it is all it'll need to convince some voters, but I get the nagging feeling that it's vulnerable to an upset (in both categories) by
True Grit. The mixing team (who, in my opinion, should have won this category for
No Country for Old Men three years ago) has done a terrific job that's nuanced but noticeable enough to draw votes away from
Inception. Love for the film may push it across the finish line here. I'm not ballsy enough to predict it, but I smell a mini-upset in the works.
If it ends up being either
The Social Network or
The King's Speech, then there's your Best Picture sweeper right there. But those mixes are probably too subtle to register with the Academy at large.
Congrats to Greg P. Russell on his 14th career nomination for
Salt. Shame that he's destined to lose yet again. Step up, Academy! Give the man his Oscar. And while you're at it, give one to Kevin O'Connell as well.
Will win: Inception
Runner-up: True Grit
Should win: Inception
Should have been nominated: Black Swan